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Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity
dc.contributor.author | Lorenzo-Luis, Pablo | |
dc.contributor.author | Alguacil, Andrés | |
dc.contributor.author | Scalambra, Franco | |
dc.contributor.author | Puerta, Adrián | |
dc.contributor.author | Gonzalez Bakker, Aday | |
dc.contributor.author | Mendoza, Zenaida | |
dc.contributor.author | Padrón, José M. | |
dc.contributor.author | Romerosa, Antonio | |
dc.contributor.other | Química | |
dc.contributor.other | Área de Química Inorgánica-CIESOL, Universidad de Almería, 04120 Almería, Spain. E-mail: romerosa@ual.es BioLab, Instituto Universitario de Bio-Orgánica ¿Antonio Gónzalez¿, Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38071 La Laguna, Spain cÁrea de Química Inorgánica, Departamento | |
dc.date.accessioned | 2023-12-13T21:08:57Z | |
dc.date.available | 2023-12-13T21:08:57Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | http://riull.ull.es/xmlui/handle/915/34772 | |
dc.description | DOI: 10.1039/d3dt01284k | |
dc.description.abstract | Complexes [{RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2 -N,N’-CuCl}2-µ-Cl-µOCH3](CF3SO3)2·(CH3OH)4 (1) and [{RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2 - N,N’-NiCl}2-µ-Cl-µ-OH](CF3SO3)2 (2) have been synthesized and characterized. Their antiproliferative activities were assessed against six human solid tumours showing nanomolar GI50 values. The effects of 1 and 2 on SW1573 cells colony formation, HeLa cells action mechanism and their interaction with the pBR322 DNA plasmid were evaluated. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.relation.ispartofseries | Dalton Transactions, 2023, 52, 9541 | |
dc.rights | Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional) | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES | |
dc.title | Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1039/d3dt01284k |