Complexes [{RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2
-N,N’-CuCl}2-µ-Cl-µOCH3](CF3SO3)2·(CH3OH)4 (1) and [{RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2
-
N,N’-NiCl}2-µ-Cl-µ-OH](CF3SO3)2 (2) have been synthesized and
characterized. Their antiproliferative activities were assessed against
six human solid tumours showing nanomolar GI50 values. The effects
of 1 and 2 on SW1573 cells colony formation, HeLa cells action
mechanism and their interaction with the pBR322 DNA plasmid were
evaluated.
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