Altered expression of the tachykinins substance p/neurokinin a/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors
in uterine leiomyomata.

Báez Quintana, Delia Rosa; González Santana, Ayoze; Marrero Hernández, Sara; Dorta, Idaira; Hernández, Mariano; Pinto, Francisco María; Bello, Aixa R.; Candenas, Luz; Almeida, Teresa A.

doi:10.1016/j.fertnstert.2016.07.007

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Fecha

2016

URI

http://riull.ull.es/xmlui/handle/915/35153

Resumen

Mammalian tachykinins (TKs) are a family of biologically active and structurally related peptides derived from three different genes: TAC1 encodes for substance P (SP) and neurokinin A (NKA), TAC3 encodes for neurokinin B (NKB), and TAC4 encodes for hemokinin-1 (HK-1) (1, 2). Tachykinins exert most of their actions by interacting with specific G protein–coupled membrane receptors: neurokinin 1 receptor (NK1R), NK2R, and NK3R encoded by the TACR1, TACR2, and TACR3.

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