Synthesis and antiproliferative activity of new 2-glyco-3-nitro-2H-chromenes

Padrón Carrillo, José Manuel; Luque Agudo, Verónica; Albarrán Velo,  Jesús; Light, Mark. E.; Román, Emilio; Serrano, José A.; Gil, Victoria

doi:10.1016/j.bioorg.2019.03.016

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Date

2019

URI

http://riull.ull.es/xmlui/handle/915/35361

Abstract

3‐nitro‐2H‐chromenes and derivatives are compounds with diverse biological activity, among them, new 2‐glyco‐3‐nitro‐2H‐chromenes have been prepared by one‐pot oxa‐Michael‐Henry‐ dehydration reactions between carbohydrate‐derived nitroalkenes and several salicylaldehydes, using a minimal amount of solvent and DBU as catalyst. The antiproliferative activity of these new compounds has been evaluated against a panel of six human solid tumor cell lines, and compared to pharmacological reference compounds, finding that their activities are in the low micromolar range and that some of them are more effective than the standards.

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Except where otherwise noted, this item's license is described as Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)