Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count.

Valenzuela Fernández, Agustín; Ruiz de León, María J.; Jiménez Sousa, María A.; Moreno, Santiago; García, Marcial; Gutiérrez Rivas, Mónica; León, Agathe; Montero Alonso, Marta; González García, Juan; Resino, Salvador; Rallón, Norma; Benito, José M.; Vallejo, Alejandro

doi:10.1016/j.jmii.2018.07.007

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Fecha

2019

URI

http://riull.ull.es/xmlui/handle/915/35337

Resumen

Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137–0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.

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